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On the positive side, understanding CGRP role in bone metabolism opens possibilities for targeted approaches that could selectively enhance its bone-protective effects without triggering unwanted vascular effects

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While most work to date on FeS proteins using Mössbauer spectroscopy has examined frozen biological samples 37,38,39 , these considerations, coupled with earlier work on freeze-dried iron-oxide nanoparticles 40 , and the findings reported below, suggest that lyophilization of prebiotic FeS clusters is an appropriate, if not yet fully validated, methodology